Ogbonna Onyekachi Henry, Garcon Marie Carmel, Syrigos Kostas N, Saif Muhammad Wasif
Section of GI Cancers and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA.
Columbia University Medical Center, New York, NY 10032, USA.
Case Rep Med. 2013;2013:705092. doi: 10.1155/2013/705092. Epub 2013 Nov 17.
Background. Pancreatic tumors are rare and could arise from either the exocrine (ductal and acinar cells) or the endocrine (neuroendocrine cells) components of the pancreas. In some instances, the occurrence of pancreatic tumors comprising both acinar cells and neuroendocrine cells, with neuroendocrine cells making up more than 30% of the tumor, has been identified. This unique entity has been referred to as mixed acinar-neuroendocrine carcinoma (MANEC). Only about 20 such cases have been reported in the literature. Case Report. We report an interesting case of MANEC with neuroendocrine cell predominance in a woman presenting with epigastric pain secondary to a pancreatic mass with acinar and endocrine differentiation. She underwent surgical resection of the tumor and was offered adjuvant treatment chemotherapy with carboplatin, etoposide, and radiotherapy for positive tumor resection margins. Conclusions. Given the paucity of the cases of MANEC, continuous reporting of these cases when identified should be encouraged to aid oncologists in understanding the disease and help establish standardized management.
背景。胰腺肿瘤较为罕见，可起源于胰腺的外分泌部（导管和腺泡细胞）或内分泌部（神经内分泌细胞）。在某些情况下，已发现存在同时包含腺泡细胞和神经内分泌细胞的胰腺肿瘤，其中神经内分泌细胞占肿瘤的比例超过30%。这种独特的实体被称为混合性腺泡-神经内分泌癌（MANEC）。文献中仅报道了约20例此类病例。病例报告。我们报告了一例有趣的以神经内分泌细胞为主的MANEC病例，患者为一名女性，因胰腺肿块伴有腺泡和内分泌分化而出现上腹部疼痛。她接受了肿瘤手术切除，并因肿瘤切除边缘阳性而接受了卡铂、依托泊苷辅助化疗及放疗。结论。鉴于MANEC病例稀少，应鼓励在确诊时持续报告这些病例，以帮助肿瘤学家了解该疾病并有助于建立标准化管理。
