Molecular cloning of a protective antigen of schistosomes.
作者信息
Balloul J M, Sondermeyer P, Dreyer D, Capron M, Grzych J M, Pierce R J, Carvallo D, Lecocq J P, Capron A
出版信息
Nature. 1987;326(6109):149-53. doi: 10.1038/326149a0.
DOI:10.1038/326149a0
PMID:2434863
Abstract
The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response. Immunization of rats and hamsters with this protein leads to significant protection against a natural challenge infection with live cercariae.
摘要
Zotero 插件