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Molecular cloning of a protective antigen of schistosomes.

作者信息

Balloul J M, Sondermeyer P, Dreyer D, Capron M, Grzych J M, Pierce R J, Carvallo D, Lecocq J P, Capron A

出版信息

Nature. 1987;326(6109):149-53. doi: 10.1038/326149a0.

DOI:10.1038/326149a0
PMID:2434863
Abstract

The complementary DNA sequence encoding the Mr 28,000 antigen of Schistosoma mansoni has been isolated and expressed in Escherichia coli. Experimental vaccination of rats, hamsters and monkeys with a recombinant fusion protein induces a strongly cytotoxic antibody response. Immunization of rats and hamsters with this protein leads to significant protection against a natural challenge infection with live cercariae.

摘要

相似文献

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Molecular cloning of a protective antigen of schistosomes.
Nature. 1987;326(6109):149-53. doi: 10.1038/326149a0.
2
Protective immunity in baboons vaccinated with a recombinant antigen or radiation-attenuated cercariae of Schistosoma mansoni is antibody-dependent.用重组抗原或曼氏血吸虫辐射减毒尾蚴接种的狒狒中的保护性免疫是抗体依赖性的。
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A purified 28,000 dalton protein from Schistosoma mansoni adult worms protects rats and mice against experimental schistosomiasis.从曼氏血吸虫成虫中提纯的一种28000道尔顿的蛋白质可保护大鼠和小鼠免受实验性血吸虫病的侵害。
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Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003 Nov;35(11):981-5.

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