Cui Guanghe, Yang Zhi, Zhang Wenxiao, Li Baowei, Sun Fang, Xu Cui, Wang Kun
Department of Ultrasonic Medicine, The Affiliated Hospital of Binzhou Medical College, Binzhou, Shandong 256603, P.R. China.
Exp Ther Med. 2014 Jan;7(1):233-235. doi: 10.3892/etm.2013.1377. Epub 2013 Oct 31.
This study aimed to explore the assessment value of virtual touch quantization (VTQ) for the clinicopathological typing of renal fibrosis. The quantitative detection of 76 patients with nephropathy was performed using acoustic radiation force impulse imaging (ARFI). The extent of the renal fibrosis in each patient was confirmed using ultrasound-guided biopsy pathology. The VTQ values were compared with the degree of renal fibrosis in order to analyze the correlation between them. Patients were divided pathologically into four groups, as follows: non-fibrosis (n=14), mild fibrosis (n=40), moderate fibrosis (n=21) and severe fibrosis (n=1). Compared with the non-fibrosis group, the VTQ values of the mild and moderate fibrosis groups were significantly increased (P<0.01); however, there was no significant difference between the VTQ values of the mild and moderate fibrosis groups (P>0.05). According to the receiver operating characteristic (ROC) curve, a VTQ value of renal parenchyma of >1.67 m/sec was determined to be an indicator of renal fibrosis, with a sensitivity of 86.3% and a specificity of 83.3%. VTQ technology may be significant in the assessment of the extent of renal fibrosis.
本研究旨在探讨虚拟触诊组织量化（VTQ）对肾纤维化临床病理分型的评估价值。采用声辐射力脉冲成像（ARFI）技术对76例肾病患者进行定量检测。通过超声引导下穿刺活检病理检查确定每位患者的肾纤维化程度。比较VTQ值与肾纤维化程度，以分析两者之间的相关性。患者按病理结果分为四组，分别为：无纤维化组（n = 14）、轻度纤维化组（n = 40）、中度纤维化组（n = 21）和重度纤维化组（n = 1）。与无纤维化组相比，轻度和中度纤维化组的VTQ值显著升高（P < 0.01）；然而，轻度和中度纤维化组的VTQ值之间无显著差异（P > 0.05）。根据受试者工作特征（ROC）曲线，肾实质VTQ值>1.67 m/sec被确定为肾纤维化的指标，其灵敏度为86.3%，特异度为83.3%。VTQ技术在评估肾纤维化程度方面可能具有重要意义。
