自闭症中的言语和语言障碍：行为学与神经影像学的见解
Speech and Language Impairments in Autism: Insights from Behavior and Neuroimaging.
作者信息
Mody Maria, Belliveau John W
机构信息
MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Department of Radiology, Charlestown, MA.
出版信息
N Am J Med Sci (Boston). 2013;5(3):157-161. doi: 10.7156/v5i3p157.
Abstract
A failure to develop language is one of the earliest signs of autism. The ability to identify the neural signature of this deficit in very young children has become increasingly important, given that the presence of speech before five years of age is the strongest predictor for better outcomes in autism. This review consolidates what is known about verbal and preverbal precursors of language development as a framework for examining behavioral and brain anomalies related to speech and language in autism spectrum disorders. Relating the disruptions in the speech network to the social deficits observed will provide promising targets for behavioral and pharmacological interventions in ASD.
摘要
语言发育迟缓是自闭症最早出现的症状之一。鉴于五岁前出现语言能力是自闭症患者预后较好的最强预测指标，识别幼儿期这种缺陷的神经特征的能力变得越来越重要。这篇综述整合了关于语言发展的言语和前言语先兆的已知信息，以此作为一个框架，来研究自闭症谱系障碍中与言语和语言相关的行为及大脑异常情况。将言语网络的紊乱与所观察到的社交缺陷联系起来，将为自闭症谱系障碍的行为和药物干预提供有前景的靶点。
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