一种针对与细胞定义的Dw14决定簇紧密相关的HLA - DR4亚类型II类抗原的同种抗体。

An alloantibody against a class II antigen subtypic to HLA-DR4 and strongly associated with the cellularly defined Dw14 determinant.

作者信息

Jakobsen B K, Platz P, Ryder L P, Svejgaard A

出版信息

Tissue Antigens. 1986 Nov;28(5):313-7. doi: 10.1111/j.1399-0039.1986.tb00501.x.

DOI:10.1111/j.1399-0039.1986.tb00501.x

Abstract

A pregnancy-induced alloantibody has allowed definition of a class II HLA antigen, AE, which has a frequency of about 10% in Danes, is completely included in DR4, and highly significantly (p = 10(-9)) associated with the cellularly defined Dw14 determinant which is completely included in AE. AE is absent on Dw4 and Dw13 cells, but was also found on one Dw15 HTC and in two of four Dw10-positive cells. It is in positive linkage disequilibrium with B40 but not with B15 or B44. It is hypothesized that the AE specificity is due to the co-occurrence of an arginine in position 71 and an alanine in position 86 of the first domain of the DR beta 1 chain. However, it cannot be excluded that this antigen belongs to another class II series.

摘要

一种妊娠诱导的同种抗体已确定了一种II类HLA抗原，即AE，其在丹麦人中的频率约为10%，完全包含在DR4中，并且与细胞定义的Dw14决定簇高度显著相关（p = 10⁻⁹），而Dw14决定簇完全包含在AE中。Dw4和Dw13细胞上不存在AE，但在一个Dw15 HTC以及四个Dw10阳性细胞中的两个细胞上也发现了AE。它与B40呈正连锁不平衡，但与B15或B44无此关系。据推测，AE特异性是由于DRβ1链第一结构域第71位的精氨酸和第86位的丙氨酸同时出现所致。然而，不能排除这种抗原属于另一个II类系列。