Department of Chemistry, University of California, Irvine , Irvine, California 92697, United States.
J Am Chem Soc. 2017 Aug 2;139(30):10208-10211. doi: 10.1021/jacs.7b05327. Epub 2017 Jul 13.
Over the past 40 years, intramolecular hydroacylation has favored five-membered rings, in preference to four membered rings. Herein, we report a catalyst derived from earth-abundant cobalt that enables preparation of cyclobutanones, with excellent regio-, diastereo-, and enantiocontrol, under mild conditions (2 mol % catalyst loading and as low as 50 °C).
在过去的 40 年中，分子内氢酰化反应有利于五元环的形成，而不利于四元环的形成。在此，我们报告了一种源自丰富的钴的催化剂，它可以在温和的条件下（2 摩尔%的催化剂负载量和低至 50°C），极好地控制区域选择性、非对映选择性和对映选择性地制备环丁酮。
