Aubert N, Mauzac M, Jozefonvicz J
Biomaterials. 1987 Jan;8(1):24-9. doi: 10.1016/0142-9612(87)90023-8.
Hydrogels have been prepared by binding various amino acids to Sephadex derivatives bearing carboxymethyl and sulphonated benzylamide groups. Depending on the chemical nature and content of the amino acid substituent, these insoluble strongly hydrophilic materials may absorb 7 to 19 volumes of buffer per volume of dry material. These hydrogels present antithrombic activity in relation to their swelling ratio. The adsorption of thrombin might partially explain the anticoagulant effect as shown by the evaluated affinity constants between the hydrogels and the enzyme i.e. 1 to 2 X 10(6) I/M.
通过将各种氨基酸与带有羧甲基和磺化苄基酰胺基团的葡聚糖衍生物结合，制备了水凝胶。根据氨基酸取代基的化学性质和含量，这些不溶性的强亲水性材料每体积干物质可吸收7至19体积的缓冲液。这些水凝胶因其溶胀率而具有抗血栓活性。凝血酶的吸附可能部分解释了抗凝作用，如水凝胶与该酶之间的评估亲和常数所示，即1至2×10(6) I/M。
