Fischer A M, Mauzac M, Tapon-Bretaudiere J, Jozefonvicz J
Biomaterials. 1985 May;6(3):198-202. doi: 10.1016/0142-9612(85)90010-9.
The mechanism of anticoagulant activity of dextrans substituted with carboxylic and benzylamide sulphonate groups is studied by various coagulation tests. These derivatives exhibit a heparin-like antithrombic activity which requires the presence of antithrombin III; however they are less effective than heparin on a weight basis. They also exert a direct antithrombic activity by an antithrombic III independent pathway; but this action is negligible compared to the thrombin inhibition observed in the presence of antithrombin III. Dextran derivatives have been prepared with antithrombic properties similar to those of heparin.
通过各种凝血试验研究了用羧基和苄基酰胺磺酸盐基团取代的葡聚糖的抗凝活性机制。这些衍生物表现出类似肝素的抗血栓形成活性，这需要抗凝血酶III的存在；然而，按重量计算，它们的效果不如肝素。它们还通过抗凝血酶III非依赖性途径发挥直接抗血栓形成活性；但与在抗凝血酶III存在下观察到的凝血酶抑制作用相比，这种作用可以忽略不计。已经制备出了具有与肝素相似抗血栓特性的葡聚糖衍生物。
