Mauzac M, Aubert N, Jozefonvicz J
Biomaterials. 1982 Oct;3(4):221-4. doi: 10.1016/0142-9612(82)90023-0.
Crosslinked dextrans (Sephadex) bearing essentially carboxymethyl, benzylsulphonate and alpha-amino acid groups have been synthesized. The antithrombic activity of the resins may be the result of a cooperative effect between the functional groups. The binding of benzylsulphonate to carboxymethylated Sephadex endows these materials with activity. However the highest activity is obtained when the resins contain simultaneously benzylsulphonate, alpha-amino acid and carboxylic acid groups.
已合成了主要带有羧甲基、苄基磺酸酯和α-氨基酸基团的交联葡聚糖（葡聚糖凝胶）。这些树脂的抗血栓活性可能是官能团之间协同作用的结果。苄基磺酸酯与羧甲基化葡聚糖凝胶的结合赋予了这些材料活性。然而，当树脂同时含有苄基磺酸酯、α-氨基酸和羧酸基团时，活性最高。
