Xiaomei Zhang, PhD, Department of Pediatrics, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, People's Republic of China.
Jinghui Sun, MD, Department of Pediatrics, The First Hospital of Jilin University, 71 Xinmin Street, Changchun, Jilin 130021, People's Republic of China.
Pak J Med Sci. 2013 Jan;29(1):227-30. doi: 10.12669/pjms.291.2713.
Two sets of monozygotic (MZ) twins with Kawasaki disease (KD) from two different families are reported. Twin set 1, previously healthy 71-day-old MZ twin girls were diagnosed with incomplete KD and pneumonia. The symptoms occurred at the same time in both girls. Both girls had ectasia of right coronary arteries. In twin set 2, the younger of 18-month-old MZ twin boys was diagnosed with KD and bronchitis. After 53 days, his elder brother was diagnosed with the same disease. The symptoms occurred at different time, but were almost identical. Neither boy displayed coronary artery changes. These findings support the hypothesis that genes susceptible to KD and coronary-artery lesions may exist in families. The different clinical characteristics among MZ twins from different families also suggest diverse and complex nature of KD.
现报道 2 对来自不同家庭的患川崎病（KD）的同卵（MZ）双胞胎。第一对双胞胎，是一对 71 天大的健康的 MZ 双胞胎女孩，被诊断为不完全性 KD 和肺炎。两个女孩的症状同时出现。两个女孩的右冠状动脉均有扩张。第二对双胞胎，是一对 18 个月大的 MZ 双胞胎男孩，弟弟被诊断为 KD 和支气管炎。53 天后，哥哥也被诊断出患有同样的疾病。两个男孩的症状出现时间不同，但几乎完全相同。两个男孩均未出现冠状动脉变化。这些发现支持了这样一种假设，即易患 KD 和冠状动脉病变的基因可能存在于家庭中。来自不同家庭的 MZ 双胞胎的不同临床特征也表明 KD 具有多样化和复杂性。
