Hulya Parildar, MD, Department of Family Medicine, Baskent University Istanbul Hospital, Istanbul, Turkey.
Oyku Gulmez, MD, Department of Cardiology, Baskent University Istanbul Hospital, Istanbul, Turkey.
Pak J Med Sci. 2013 Apr;29(2):495-9. doi: 10.12669/pjms.292.3133.
We aimed to assess carotid intima media thickness (CIMT) and serum high-sensitivity C-reactive protein (hs-CRP) levels as estimated markers of subclinical atherosclerosis and inflammation in prediabetic patients.
One hundred and ten patients were defined as prediabetic and seventy-six subjects (age and sex matched) were assigned as control group in our cross sectional study. Bilateral CIMT measurements and hs-CRP levels were evaluated.
The prevalance of hypertension, hyperlipidemia, angiotensin receptor blockers and antihyperlipidemic medication use were statistically higher in the prediabetic group. Serum hs-CRP levels, left, right and maximum CIMT were statistically higher among prediabetics compared to control group. There was a positive, significant correlation between left, right, maximum CIMT and fasting blood glucose, HbA1c, hs-CRP levels and BMI.
Recognising and focusing on the intervention of prediabetic state as early as possible and identifying the susceptible patients who may benefit from more aggressive preventive therapy is an important issue of primary prevention of diabetes and cardiovascular diseases.
我们旨在评估颈动脉内膜中层厚度（CIMT）和血清高敏 C 反应蛋白（hs-CRP）水平，作为亚临床动脉粥样硬化和炎症的预估标志物在糖尿病前期患者中的作用。
在我们的这项横断面研究中，110 名患者被定义为糖尿病前期，76 名（年龄和性别匹配）患者被分配为对照组。评估了双侧 CIMT 测量值和 hs-CRP 水平。
与对照组相比，糖尿病前期患者中高血压、高血脂、血管紧张素受体阻滞剂和降脂药物的使用更为普遍。与对照组相比，糖尿病前期患者的血清 hs-CRP 水平、左、右和最大 CIMT 均更高。左、右、最大 CIMT 与空腹血糖、HbA1c、hs-CRP 水平和 BMI 呈正相关，且具有统计学意义。
尽早识别和关注糖尿病前期状态，并确定可能从更积极的预防治疗中获益的易感患者，是糖尿病和心血管疾病一级预防的重要问题。
