症状和生活质量：癌症患者在干细胞移植前后的变化。
Symptoms and Quality of Life: Before and after stem cell transplantation in cancer.
出版信息
Pak J Med Sci. 2013 May;29(3):803-8. doi: 10.12669/pjms.293.3290.
Abstract
OBJECTIVE
This study was conducted thinking that it was extremely important in terms of the disease and treatment to assess the symptoms that may be encountered before and after a stem cell transplantation and quality of life.
METHODOLOGY
A prospective longitudinal design was used.The study was completed in two years on 82 patients who underwent transplantation at the bone marrow transplantation unit. Data were collected using a questionnaire, the Edmonton Symptom Assessment Scale, and the Short Form-36 quality of life scale.
RESULTS
It was observed that the patients had low mean scores of physical and mental quality of life both before and after transplantation; there was an increase in the mean scores of all the symptoms and primarily of fatigue after the stem cell transplantation as compared to before it; and the mean scores of physical and mental quality of life further declined (p<0.05).
CONCLUSION
Quality of life of patients who underwent stem cell transplantation is adversely affected in the periods immediately before and after transplantation. Patients' quality of life worsens as the severity of symptoms experienced by patients increases.
摘要
目的
本研究认为，评估干细胞移植前后可能出现的症状和生活质量对于疾病和治疗至关重要。
方法
采用前瞻性纵向设计。在骨髓移植病房对 82 名接受移植的患者进行了为期两年的研究。使用问卷、埃德蒙顿症状评估量表和简明 36 健康状况量表收集数据。
结果
研究发现，患者在移植前后的身体和心理健康生活质量评分均较低；与移植前相比，干细胞移植后所有症状的平均评分，尤其是疲劳感，均有所增加；身体和心理健康生活质量的平均评分进一步下降（p<0.05）。
结论
接受干细胞移植的患者在移植前后的生活质量受到不利影响。随着患者症状的严重程度增加，患者的生活质量恶化。
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