烟酸（维生素 B3 或烟酰胺）对糖尿病和非糖尿病大鼠血脂谱的影响。
Effect of Nicotinic Acid (Vitamin B3 or Niacin) on the lipid profile of diabetic and non - diabetic rats.
机构信息
Dr. Talmeez Zeb Shah, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, akistan.
Dr. Abdul Basit Ali, Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, akistan.
出版信息
Pak J Med Sci. 2013 Sep;29(5):1259-64. doi: 10.12669/pjms.295.4193.
OBJECTIVE
To determine the efficacy of nicotinic acid on the lipid profile of diabetic and non diabetic rats.
METHODS
This was an experimental study done at the Institute of Molecular Biology and Biotechnology, The University of Lahore, Pakistan between May 2010 to July 2010. Nicotinic acid was administered to a hypercholesterolemic group and a hypercholesterolemic + diabetic Group of Albino rats for 42 days and response to therapy was recorded on day 21 and day 42 of the experiment. Comparison among these two groups as well as three control groups was determined by Analysis of Variance (ANOVA) and differences were considered significant at (P<0.05). A total of 50 rats were included in the study.
RESULTS
Lipid profile of the hypercholesterolemic group as well as hypercholesterolemic + diabetic group as compared with the control groups showed highly significant improvement on the day 21 and day 42 of the experiment. The values of serum total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) cholesterol and total lipids (TL) showed highly significant decrease whereas serum high density lipoprotein (HDL) cholesterol showed highly significant increase.
CONCLUSION
Nicotinic acid is the most effective agent available in increasing HDL cholesterol and lowering serum TC, triglycerides (TG), LDL cholesterol and TL in hypercholesterolemic Diabetic and hypercholesterolemic non-diabetic Albino rats.
目的
评估烟酸对糖尿病和非糖尿病大鼠血脂谱的影响。
方法
本实验于 2010 年 5 月至 7 月在巴基斯坦拉合尔大学分子生物学与生物技术研究所进行。将烟酸分别给予高胆固醇血症大鼠组和高胆固醇血症合并糖尿病大鼠组，连续给药 42 天，分别于第 21 天和第 42 天观察治疗效果。采用方差分析（ANOVA）对两组高脂血症大鼠及三组正常对照大鼠的结果进行比较，以 P<0.05 为差异有统计学意义。共纳入 50 只大鼠进行研究。
结果
与对照组相比，高胆固醇血症组和高胆固醇血症合并糖尿病组大鼠的血脂谱在实验第 21 天和第 42 天均有显著改善。血清总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL）胆固醇和总脂质（TL）水平显著降低，而高密度脂蛋白（HDL）胆固醇水平显著升高。
结论
烟酸是增加 HDL 胆固醇、降低血清 TC、TG、LDL 胆固醇和 TL 的最有效药物，可有效改善高胆固醇血症合并糖尿病和非糖尿病的白化病大鼠的血脂谱。
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