Hellenbrand W K, Klassen G A, Armour J A, Sezerman O, Paton B
Can J Physiol Pharmacol. 1986 Dec;64(12):1463-72. doi: 10.1139/y86-248.
The velocity of blood in a major epicardial coronary vein accompanying the left anterior descending coronary artery of dogs was measured by means of a 140-micron fiber optic probe connected to a laser Doppler velocimeter. Right atrial pressure, left ventricular intramyocardial and cavity pressures, aortic pressure, as well as peripheral and central coronary venous pressures were compared with the velocity of blood measured in the epicardial coronary vein midway between the sites of the catheters measuring proximal and distal coronary vein pressures. During control conditions, coronary vein velocity was 14-18 cm/s during systole and 1.0-2.1 cm/s during diastole. Right stellate ganglion stimulation, norepinephrine or isoproterenol increased diastolic coronary vein velocity significantly, whereas left stellate ganglion stimulation did not. Average peak systolic velocity was not affected by these interventions. During these positive inotropic interventions, the peak coronary vein velocity usually occurred later in the cardiac cycle than during control conditions. Positive inotropic interventions appeared to decrease coronary vein velocity during systole and increase it during diastole. Left vagosympathetic trunk stimulation decreased diastolic but not systolic coronary vein velocity and usually caused peak coronary vein velocity to occur earlier in the cardiac cycle than during control states. Changes induced by vagosympathetic trunk stimulation usually occurred within one cardiac cycle. It is concluded that coronary vein blood velocity can be influenced by the autonomic nervous system.
通过连接激光多普勒测速仪的140微米光纤探头，测量了犬左前降支冠状动脉伴行的一条主要心外膜冠状静脉内的血流速度。将右心房压力、左心室内心肌压力和心腔压力、主动脉压力以及外周和中心冠状静脉压力，与在测量近端和远端冠状静脉压力的导管部位之间的中点处的心外膜冠状静脉中测得的血流速度进行了比较。在对照条件下，收缩期冠状静脉流速为14 - 18厘米/秒，舒张期为1.0 - 2.1厘米/秒。刺激右侧星状神经节、给予去甲肾上腺素或异丙肾上腺素可显著增加舒张期冠状静脉流速，而刺激左侧星状神经节则无此作用。这些干预措施对平均收缩期峰值流速无影响。在这些正性肌力干预过程中，冠状静脉峰值流速通常比对照条件下更晚出现在心动周期中。正性肌力干预似乎在收缩期降低冠状静脉流速，在舒张期增加流速。刺激左迷走交感干降低舒张期而非收缩期冠状静脉流速，且通常使冠状静脉峰值流速比对照状态下更早出现在心动周期中。迷走交感干刺激引起的变化通常在一个心动周期内发生。得出的结论是，冠状静脉血流速度可受自主神经系统影响。
