Grillon C, Buchsbaum M S
Electroencephalogr Clin Neurophysiol. 1987 Apr;66(4):337-48. doi: 10.1016/0013-4694(87)90031-9.
EEG activity was recorded in 11 normal subjects and 19 patients with generalized anxiety disorder (GAD) at rest and while they were viewing a series of ten 4 sec continuous lights. Topographical cortical changes were assessed using 32-channel EEG power estimate maps. The percent changes from baseline to stimulation, for the first 5 and the last 5 light stimuli, were calculated and topographically mapped. Patients with GAD showed less decrease in alpha activity during the first 5 stimuli and more alpha activity during the last 5 stimuli in comparison to normal controls. Delta, theta, alpha, beta I and beta II did not show any difference during the resting periods. The topographical distribution of response to light was different in each group. Normal controls had a parieto-occipital reactivity and GAD patients a centro-parietal one with the maximum difference between the two groups being located in the occipital region. During the stimulation, beta I activity was decreased in controls and increased in patients. The diminishing reactivity of the patients is interpreted as a diminution of attention to external stimulation because of competing internal interferences. The pattern of regional reactivity suggests the importance of the centro-parietal and/or occipital regions in anxiety.
对11名正常受试者和19名广泛性焦虑症（GAD）患者在静息状态以及观看一系列十个4秒连续灯光时的脑电图（EEG）活动进行了记录。使用32通道EEG功率估计图评估皮层地形变化。计算并绘制了前5个和后5个光刺激从基线到刺激时的百分比变化地形图。与正常对照组相比，GAD患者在前5个刺激期间α活动减少较少，而在后5个刺激期间α活动较多。在静息期，δ、θ、α、βI和βII没有任何差异。每组对光反应的地形分布不同。正常对照组有顶枕反应性，GAD患者有中央顶叶反应性，两组之间的最大差异位于枕叶区域。在刺激期间，对照组的βI活动减少，而患者的βI活动增加。患者反应性的降低被解释为由于竞争性内部干扰而导致对外部刺激的注意力下降。区域反应模式表明中央顶叶和/或枕叶区域在焦虑中的重要性。
