Department of Public Health, Academic Medical Center, Amsterdam, The Netherlands; Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Diabetes Res Clin Pract. 2014 Jan;103(1):127-32. doi: 10.1016/j.diabres.2013.10.014. Epub 2013 Nov 12.
Evidence of ethnic disparities in the conversion of prediabetes to type 2 diabetes is scarce. We studied the association of impaired fasting glucose (IFG) and fasting plasma glucose (FPG) with the 10-year cumulative incidence of type 2 diabetes in three ethnic groups.
We analyzed data for 90 South-Asian Surinamese, 190 African-Surinamese, and 176 ethnic Dutch that were collected in the periods 2001-2003 and 2011-2012. We excluded those with type 2 diabetes or missing FPG data. We defined baseline IFG as FPG of 5.7-6.9 mmol/L. We defined type 2 diabetes at follow-up as FPG ≥ 7.0 mmol/L, HbA1c ≥ 48 mmol/mol (6.5%), or self-reported type 2 diabetes.
10-Year cumulative incidences of type 2 diabetes were: South-Asian Surinamese, 18.9%; African-Surinamese, 13.7%; ethnic Dutch, 4.5% (p<0.05). The adjusted association of baseline IFG and FPG with the 10-year cumulative incidence of type 2 diabetes was stronger for South-Asian Surinamese than for African-Surinamese and ethnic Dutch. The IFG (compared to normoglycaemia) ORs were 11.1 [3.0-40.8] for South-Asian Surinamese, 5.1 [2.0-13.3] for African-Surinamese, and 2.2 [0.5-10.1] for ethnic Dutch.
The 10-year cumulative incidence of type 2 diabetes was higher and associations with baseline IFG and FPG were stronger among South-Asian Surinamese and African-Surinamese than among ethnic Dutch. Our findings confirm the high risk of type 2 diabetes in South-Asians and suggest more rapid conversion in populations of South-Asian origin and (to a lesser extent) African origin than European origin.
有关糖尿病前期向 2 型糖尿病转化的种族差异的证据很少。我们研究了空腹血糖受损（IFG）和空腹血浆葡萄糖（FPG）与三种族裔的 10 年累积 2 型糖尿病发病率之间的关联。
我们分析了 2001-2003 年和 2011-2012 年期间收集的 90 名南亚苏里南人、190 名非洲苏里南人和 176 名荷兰裔的数据。我们排除了患有 2 型糖尿病或 FPG 数据缺失的人。我们将基线 IFG 定义为 FPG 为 5.7-6.9mmol/L。我们将随访时的 2 型糖尿病定义为 FPG≥7.0mmol/L、HbA1c≥48mmol/mol（6.5%）或自我报告的 2 型糖尿病。
10 年累积 2 型糖尿病发病率为：南亚苏里南人 18.9%；非洲苏里南人 13.7%；荷兰裔 4.5%（p<0.05）。与非洲苏里南人和荷兰裔相比，基线 IFG 和 FPG 与 10 年累积 2 型糖尿病发病率的调整关联在南亚苏里南人中更强。与正常血糖相比，IFG（与正常血糖相比）的 OR 分别为南亚苏里南人 11.1[3.0-40.8]、非洲苏里南人 5.1[2.0-13.3]和荷兰裔 2.2[0.5-10.1]。
南亚苏里南人和非洲苏里南人的 2 型糖尿病 10 年累积发病率更高，与基线 IFG 和 FPG 的关联更强。我们的研究结果证实了南亚裔人群患 2 型糖尿病的高风险，并表明南亚裔和（在较小程度上）非洲裔人群的 2 型糖尿病转化速度比欧洲裔人群更快。
