Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Eur J Radiol. 2014 Feb;83(2):391-7. doi: 10.1016/j.ejrad.2013.11.001. Epub 2013 Nov 23.
To prospectively and directly compare oxygen-enhanced (O2-enhanced) MRI with thin-section CT for pulmonary functional loss and disease severity assessment in connective tissue disease (CTD) patients with interstitial lung disease (ILD).
Thin-section CT, O2-enhanced MRI, pulmonary function test and serum KL-6 were administered to 36 CTD patients with ILD (23 men, 13 women; mean age: 63.9 years) and nine CTD patients without ILD (six men, and three women; mean age: 62.0 years). A relative-enhancement ratio (RER) map was generated from O2-enhanced MRI and mean relative enhancement ratio (MRER) for each subject was calculated from all ROI measurements. CT-assessed disease severity was evaluated with a visual scoring system from each of the thin-section CT data. MRER and CT-assessed disease severities of CTD patients with and without ILD were then statistically compared. To assess capability for pulmonary functional loss and disease severity assessment in CTD patients, correlations of MRER and CT-assessed disease severity with pulmonary functional parameters and serum KL-6 in all subjects were statistically determined.
MRER and CT-assessed disease severity showed significant differences between CTD patients with (MRER: 0.15 ± 0.08, CT-assessed disease severity: 13.0 ± 7.4%) and without ILD (MRER: 0.25 ± 0.06, p=0.0011; CT-assessed disease severity: 1.6 ± 1.6%, p<0.0001). MRER and CT-assessed disease severity correlated significantly with pulmonary functional parameters and serum KL-6 in all subjects (0.61 ≤ r ≤ 0.79, p<0.05).
O2-enhanced MRI was found to be as useful as thin-section CT for pulmonary functional loss and disease severity assessment of CTD patients with ILD.
前瞻性地直接比较氧增强（O2-enhanced）MRI 与薄层 CT 对结缔组织病（CTD）伴间质性肺病（ILD）患者的肺功能丧失和疾病严重程度评估。
对 36 例 CTD 伴 ILD 患者（23 名男性，13 名女性；平均年龄：63.9 岁）和 9 例 CTD 不伴 ILD 患者（6 名男性，3 名女性；平均年龄：62.0 岁）进行了薄层 CT、O2 增强 MRI、肺功能检查和血清 KL-6 检查。从 O2 增强 MRI 生成相对增强比（RER）图，并从所有 ROI 测量中计算每个受试者的平均相对增强比（MRER）。使用薄层 CT 数据的视觉评分系统评估 CT 评估的疾病严重程度。然后统计比较 CTD 伴或不伴 ILD 患者的 MRER 和 CT 评估的疾病严重程度。为了评估 O2 增强 MRI 在 CTD 患者中的肺功能丧失和疾病严重程度评估能力，对所有受试者的 MRER 和 CT 评估的疾病严重程度与肺功能参数和血清 KL-6 进行了统计学相关性分析。
CTD 伴 ILD 患者的 MRER（0.15 ± 0.08）和 CT 评估的疾病严重程度（13.0 ± 7.4%）与不伴 ILD 患者的 MRER（0.25 ± 0.06，p=0.0011；CT 评估的疾病严重程度：1.6 ± 1.6%，p<0.0001）有显著差异。MRER 和 CT 评估的疾病严重程度与所有受试者的肺功能参数和血清 KL-6 显著相关（0.61≤r≤0.79，p<0.05）。
O2 增强 MRI 与薄层 CT 一样可用于 CTD 伴 ILD 患者的肺功能丧失和疾病严重程度评估。
