介导瘙痒的感觉神经元和回路。
Sensory neurons and circuits mediating itch.
机构信息
Departments of Anesthesiology and Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8051, USA.
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, Maryland 21205, USA.
出版信息
Nat Rev Neurosci. 2014 Jan;15(1):19-31. doi: 10.1038/nrn3641.
Abstract
Chemicals that are used experimentally to evoke itch elicit activity in diverse subpopulations of cutaneous pruriceptive neurons, all of which also respond to painful stimuli. However, itch is distinct from pain: it evokes different behaviours, such as scratching, and originates from the skin or certain mucosae but not from muscle, joints or viscera. New insights regarding the neurons that mediate the sensation of itch have been gained from experiments in which gene expression has been manipulated in different types of pruriceptive neurons as well as from comparisons between psychophysical measurements of itch and the neuronal discharges and other properties of peripheral and central pruriceptive neurons.
摘要
用于诱发瘙痒的实验化学物质会引起不同的皮肤瘙痒神经元亚群的活动，这些亚群也对疼痛刺激有反应。然而，瘙痒与疼痛不同：它会引起不同的行为，如抓挠，并且起源于皮肤或某些黏膜，而不是肌肉、关节或内脏。通过对不同类型的瘙痒神经元进行基因表达的操纵实验，以及对瘙痒的心理物理测量与周围和中枢瘙痒神经元的神经元放电和其他特性进行比较，人们对介导瘙痒感觉的神经元有了新的认识。
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本文引用的文献
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