Centre National de la Recherche Scientifique (CNRS) UMR 8119 Neurophysics and Physiology Laboratory, Université Paris Descartes, Paris, France.
EMBO Rep. 2014 Jan;15(1):103-9. doi: 10.1002/embr.201337371. Epub 2013 Dec 15.
The orphan GluD2 receptor belongs to the ionotropic glutamate receptor family but does not bind glutamate. Ligand-gated GluD2 currents have never been evidenced, and whether GluD2 operates as an ion channel has been a long-standing question. Here, we show that GluD2 gating is triggered by type 1 metabotropic glutamate receptors, both in a heterologous expression system and in Purkinje cells. Thus, GluD2 is not only an adhesion molecule at synapses but also works as a channel. This gating mechanism reveals new properties of glutamate receptors that emerge from their interaction and opens unexpected perspectives regarding synaptic transmission and plasticity.
孤儿谷氨酸受体 GluD2 属于离子型谷氨酸受体家族，但不与谷氨酸结合。配体门控的 GluD2 电流从未得到证实，GluD2 是否作为离子通道发挥作用一直是一个悬而未决的问题。在这里，我们表明 GluD2 的门控由 1 型代谢型谷氨酸受体触发，无论是在异源表达系统还是在浦肯野细胞中都是如此。因此，GluD2 不仅是突触处的粘附分子，而且还作为通道发挥作用。这种门控机制揭示了谷氨酸受体相互作用产生的新特性，并为突触传递和可塑性提供了意想不到的视角。
