Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America ; Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.
PLoS One. 2013 Dec 17;8(12):e84581. doi: 10.1371/journal.pone.0084581. eCollection 2013.
Nicotine improves performance on several cognitive and sensorimotor tasks. The neuronal mechanisms associated with these changes in performance are, however, largely unknown. Functional magnetic resonance imaging (fMRI) was used to examine the effect of nicotine on neuronal response in nineteen healthy subjects while they performed an auditory-paced finger tapping task. Subjects performed the task, after receiving either a nicotine patch or placebo treatment, in a single blind, crossover design. Compared to placebo, nicotine treatment increased response in the cerebellar vermis. Increased vermal activity, in the absence of changes in other task-related regions suggests specificity in nicotine's effects.
尼古丁可改善多项认知和感觉运动任务的表现。然而，与这些表现变化相关的神经元机制在很大程度上仍是未知的。本研究采用功能磁共振成像（fMRI）技术，在 19 名健康受试者进行听觉节拍手指敲击任务时，观察尼古丁对神经元反应的影响。受试者以单盲交叉设计，在接受尼古丁贴片或安慰剂治疗后完成任务。与安慰剂相比，尼古丁治疗增加了小脑蚓部的反应。在其他与任务相关的区域没有变化的情况下，蚓部活动增加表明尼古丁作用具有特异性。
