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通过水热法利用牛废料制备矿化胶原蛋白作为有前景的生物材料

Fabrication of Mineralized Collagen from Bovine Waste Materials by Hydrothermal Method as Promised Biomaterials.

作者信息

Sheikh Faheem A, Kanjwal Muzafar A, Macossay Javier, Muhammad Muneeb A, Cantu Travis, Barakat Nasser A M, Kim Hak Yong

机构信息

Department of Chemistry, University of Texas Pan American, Edinburg, TX, 78539, USA.

Technical University of Demmak, DTU Food, Soltofts Plads, B 227. 2800. Kgs. Lyngby Denmark.

出版信息

J Biomater Tissue Eng. 2011 Dec;1(2). doi: 10.1166/jbt.2011.1017.

DOI:10.1166/jbt.2011.1017
PMID:24358449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3865788/
Abstract

In the present study, we aimed to produce mineralized-collagen by hydrothermal process. A simple method not depending on additional foreign chemicals has been employed to isolate the mineralized-collagen fibers from bovine waste. The process of extraction involves the use of hydrothermal method from available bovine bones. The structural and morphological properties of the collagen fibers were characterized by using scanning electron microscopy and transmission electron microscopy. These results indicated well received collagen fibers, having a diameter less than 1 m and with established mineral content in the individual fibers. The X-ray diffraction showed the crystalline feature of the obtained nano-compounds. The thermo gravimetric analysis was used to differentiate between the collagen and mineral parts of obtained product. Overall, the results generously indicated production of well received collagen fibers from bovine bones.

摘要

在本研究中,我们旨在通过水热法制备矿化胶原蛋白。采用了一种不依赖额外外来化学物质的简单方法,从牛废弃物中分离矿化胶原纤维。提取过程涉及使用水热法从现有的牛骨中提取。通过扫描电子显微镜和透射电子显微镜对胶原纤维的结构和形态特性进行了表征。这些结果表明,所获得的胶原纤维受到良好的接受,其直径小于1μm,且各纤维中具有确定的矿物质含量。X射线衍射显示了所获得的纳米化合物的晶体特征。热重分析用于区分所得产物中胶原蛋白和矿物质部分。总体而言,结果充分表明从牛骨中成功制备了受到良好接受的胶原纤维。

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A bone-like nano-hydroxyapatite/collagen loaded injectable scaffold.载有纳米羟磷灰石/胶原的类似骨的可注射支架。
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