Katthagen B D, Mittelmeier H
Arch Orthop Trauma Surg (1978). 1984;103(5):291-302. doi: 10.1007/BF00432417.
Multicentric osteoregeneration is a new principle of osteoinduction [31a] which can be realized with the combination of collagen and fine dispersed hydroxyapatite ceramic particles (Collapat). This was histomorphometrically proved in the present study involving 14 rabbits with 28 6-mm-wide bore holes in the distal femoral condyles. With Collapat, an average of 5 times more new bone was regenerated than in the control defects without implant. The Wilcoxon matched-pairs signed-ranks test proved the positive effect of the implant Collapat on osteoregeneration with a significance of P less than 0.0001. At sites of Collapat insertion bone regeneration begins in the 2nd week, reaches its climax in the 3rd week, and is completed after the 4th week. in the course of development the histological picture is typified by a lively bone remodeling. Bone formation can be recognized in direct contact to the apatite granules. Foreign body or allergic reactions are not observed. Remodeling of the bone is not hindered by the slowly resorbable apatite granules. About 250 human implantations have been performed in our hospital since 1979, with good results and no negative effects.
多中心骨再生是骨诱导的一种新原理[31a]，可通过胶原蛋白与细分散的羟基磷灰石陶瓷颗粒（Collapat）相结合来实现。在本研究中，对14只兔子股骨远端髁上的28个6毫米宽的钻孔进行组织形态计量学证明了这一点。使用Collapat时，新骨再生的平均量比未植入的对照缺损处多5倍。Wilcoxon配对符号秩检验证明植入物Collapat对骨再生有积极作用，P值小于0.0001，具有显著性。在Collapat植入部位，骨再生在第2周开始，在第3周达到高潮，并在第4周后完成。在发育过程中，组织学表现以活跃的骨重塑为特征。在与磷灰石颗粒直接接触处可识别出骨形成。未观察到异物或过敏反应。缓慢可吸收的磷灰石颗粒不会阻碍骨的重塑。自1979年以来，我院已进行了约250例人体植入手术，效果良好，无负面影响。
