Hedberg N M, Hunter N
J Oral Pathol. 1987 Jan;16(1):31-5. doi: 10.1111/j.1600-0714.1987.tb00673.x.
HLA-DR is a Class II histocompatibility antigen which has recently been reported to occur in increased amounts in dermal and oral lichen planus. Its expression in epithelium was previously thought to be limited to Langerhans cells. In this study, formalin-fixed sections of oral lichen planus and a variety of other oral mucosal lesions were stained with a monoclonal antibody to HLA-DR using an indirect immunofluorescence test. The expression of HLA-DR by keratinocytes did not appear to be a specific marker for lichen planus as demonstrated by the reactivity of the epithelium in a variety of lesions of the oral mucosa. If HLA-DR expression is considered to be an inducible function, perhaps in response to gamma interferon secreted by activated lymphocytes, then keratinocyte reactivity would not be expected to occur only in lichen planus.
HLA - DR是一种II类组织相容性抗原，最近有报道称其在皮肤和口腔扁平苔藓中的含量增加。其在上皮中的表达以前被认为仅限于朗格汉斯细胞。在本研究中，使用间接免疫荧光试验，用抗HLA - DR单克隆抗体对口腔扁平苔藓和各种其他口腔黏膜病变的福尔马林固定切片进行染色。口腔黏膜各种病变上皮的反应性表明，角质形成细胞表达HLA - DR似乎不是扁平苔藓的特异性标志物。如果将HLA - DR表达视为一种诱导性功能，可能是对活化淋巴细胞分泌的γ干扰素的反应，那么角质形成细胞的反应性预计不会仅在扁平苔藓中出现。
