Farthing P M, Matear P, Cruchley A T
Department of Oral Pathology, London Hospital Medical College, UK.
J Oral Pathol Med. 1990 Feb;19(2):81-5. doi: 10.1111/j.1600-0714.1990.tb00801.x.
The numbers of CD1, HLADR, HLADP and HLADQ positive, intraepithelial, dendritic cells were compared in lesions of oral lichen planus and normal oral mucosa using an immunoalkaline phosphatase technique. In normal mucosa, there were equal numbers of CD1 and HLADR positive cells but significantly fewer cells were positive for HLADP (P less than 0.001) and HLADQ (P less than 0.05). In lichen planus, the cells appeared more dendritic and equal numbers of CD1, HLADR, HLADP and HLADQ positive cells were found, with significantly more HLADP (P less than 0.01) and HLADQ (P less than 0.05) positive cells than in normal mucosa. There was no change in the number of CD1 and HLADR positive cells. These results show that although there is no change in the total number of Langerhans cells (CD1 positive cells) in lichen planus, there is an increase in Class II major histocompatibility antigen expression. This suggests that in lichen planus, Langerhans cells are immunologically active and play a role in lesion development.
采用免疫碱性磷酸酶技术，对口腔扁平苔藓病变组织和正常口腔黏膜中CD1、HLADR、HLADP和HLADQ阳性的上皮内树突状细胞数量进行了比较。在正常黏膜中，CD1和HLADR阳性细胞数量相等，但HLADP阳性细胞（P<0.001）和HLADQ阳性细胞（P<0.05）明显较少。在扁平苔藓中，细胞呈现出更多的树突状，且发现CD1、HLADR、HLADP和HLADQ阳性细胞数量相等，其中HLADP阳性细胞（P<0.01）和HLADQ阳性细胞（P<0.05）明显多于正常黏膜。CD1和HLADR阳性细胞数量没有变化。这些结果表明，虽然扁平苔藓中朗格汉斯细胞（CD1阳性细胞）总数没有变化，但II类主要组织相容性抗原表达增加。这表明在扁平苔藓中，朗格汉斯细胞具有免疫活性，并在病变发展中起作用。
