Qiu Li-peng, Long Miao-miao, Chen Da-wei
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yao Xue Xue Bao. 2013 Sep;48(9):1376-82.
Hyaluronic acid (HA) as anticancer drug carrier has become the new hot point in the field of tumor-targeted drugs delivery system in recent years. Tumor therapeutic agents could be transmitted into cells because of hyaluronic acid innate ability to recognize specific cellular receptors that overexpressed on tumor cells surface. This review introduces the basic properties and physiology foundation of hyaluronic acid. Recent research developments based on different forms of HA tumor-targeted drugs delivery systems are reviewed in particular.
近年来,透明质酸(HA)作为抗癌药物载体已成为肿瘤靶向给药系统领域的新热点。由于透明质酸具有识别肿瘤细胞表面过度表达的特定细胞受体的固有能力,肿瘤治疗药物可以被转运到细胞中。本文综述了透明质酸的基本特性和生理基础。特别综述了基于不同形式的透明质酸肿瘤靶向给药系统的最新研究进展。