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基于透明质酸的生物制药递送和肿瘤靶向药物递送系统。

Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system.

机构信息

Active Carbohydrate Research Institute, Chongqing Normal University, Chongqing, 401331, China.

School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan, 430073, China.

出版信息

J Control Release. 2018 May 28;278:122-126. doi: 10.1016/j.jconrel.2018.04.015. Epub 2018 Apr 9.

Abstract

Hyaluronic acid (HA) is a natural polysaccharide with good biocompatibility and degradability. HA and its derivatives can be used as sustained-release carriers for drugs, which can delay the release of drugs and have a long-acting effect. They can be used for the delivery of various drugs such as proteins, nucleic acids and anti-tumor drugs. HA and its derivatives can specifically bind to multiple receptors on the cell surface and can be used for targeted drug delivery, especially for the delivery of anti-tumor drugs. Thus, there are different forms of tumor-targeted drug delivery systems based on HA.

摘要

透明质酸(HA)是一种具有良好生物相容性和可降解性的天然多糖。HA 及其衍生物可用作药物的缓释载体,可延迟药物的释放,具有长效作用。它们可用于递送各种药物,如蛋白质、核酸和抗肿瘤药物。HA 及其衍生物可特异性结合细胞表面上的多个受体,并可用于靶向药物递送,特别是用于抗肿瘤药物的递送。因此,基于 HA 有不同形式的肿瘤靶向药物递送系统。

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