大量饮酒的暗适应小鼠：一种醉酒的遗传模型。
High drinking in the dark mice: a genetic model of drinking to intoxication.
机构信息
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA; Portland Alcohol Research Center, VA Medical Center, Portland, OR 97239, USA.
Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA; Portland Alcohol Research Center, VA Medical Center, Portland, OR 97239, USA.
出版信息
Alcohol. 2014 May;48(3):217-23. doi: 10.1016/j.alcohol.2013.10.007. Epub 2013 Nov 15.
Abstract
Drinking to intoxication is a critical component of risky drinking behaviors in humans, such as binge drinking. Previous rodent models of alcohol consumption largely failed to demonstrate that animals were patterning drinking in such a way as to experience intoxication. Therefore, few rodent models of binge-like drinking and no specifically genetic models were available to study possible predisposing genes. The High Drinking in the Dark (HDID) selective breeding project was started to help fill this void, with HDID mice selected for reaching high blood alcohol levels in a limited access procedure. HDID mice now represent a genetic model of drinking to intoxication and can be used to help answer questions regarding predisposition toward this trait as well as potential correlated responses. They should also prove useful for the eventual development of better therapeutic strategies.
摘要
酗酒是人类危险饮酒行为的一个关键组成部分，如狂饮。以前的酒精消费啮齿动物模型在很大程度上未能证明动物的饮酒模式会导致醉酒。因此，很少有类似狂饮的啮齿动物模型，也没有专门的遗传模型来研究可能的易感基因。高饮酒黑暗（HDID）选择育种项目开始启动，以帮助填补这一空白，HDID 小鼠通过有限的接触程序被选择达到高血酒精水平。HDID 小鼠现在代表了一种醉酒的遗传模型，可用于帮助回答有关这种特征的易感性以及潜在的相关反应的问题。它们也应该有助于最终开发更好的治疗策略。
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4
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10
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