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携带 FBXW7 突变的肺腺癌患者使用替西罗莫司治疗。

Temsirolimus therapy in a patient with lung adenocarcinoma harboring an FBXW7 mutation.

机构信息

University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, United States.

University of Pittsburgh Cancer Institute, University of Pittsburgh, School of Medicine/Hematology-Oncology, Lung and Thoracic Malignancies Program, Pittsburgh, PA 15232, United States.

出版信息

Lung Cancer. 2014 Feb;83(2):300-1. doi: 10.1016/j.lungcan.2013.11.018. Epub 2013 Dec 1.

DOI:10.1016/j.lungcan.2013.11.018
PMID:24360397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4836187/
Abstract

We report the identification of an FBXW7 mutation in a patient with adenocarcinoma of the lung, whose tumor had previously been shown to be EGFR and ALK wild type and who had previously progressed on multiple lines of systemic therapy. She experienced both clinical and radiographic benefit from treatment with the mTOR inhibitor temsirolimus.

摘要

我们报告了一例肺腺癌患者 FBXW7 突变的鉴定，该患者的肿瘤先前被证实为 EGFR 和 ALK 野生型，并且先前已经接受了多线系统治疗。她接受 mTOR 抑制剂替西罗莫司治疗后，既获得了临床获益，也获得了影像学获益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3737/4836187/c4698086e151/nihms-776091-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3737/4836187/c4698086e151/nihms-776091-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3737/4836187/c4698086e151/nihms-776091-f0001.jpg

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2
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Science. 2008 Sep 12;321(5895):1499-502. doi: 10.1126/science.1162981.
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FBXW7/hCDC4 is a general tumor suppressor in human cancer.FBXW7/hCDC4是人类癌症中的一种通用肿瘤抑制因子。
泛素连接酶FBXW7的低表达与结直肠癌患者的不良预后相关。
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FBXW7 in Cancer: What Has Been Unraveled Thus Far?癌症中的FBXW7：迄今为止已揭示了什么？
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