使用爆发持续时间和爆发间隔对低危胎儿的胎儿脑磁图活动进行定量分析。
Quantification of fetal magnetoencephalographic activity in low-risk fetuses using burst duration and interburst interval.
机构信息
Graduate Institute of Technology, University of Arkansas at Little Rock, AR, USA.
Division of Fetal and Transitional Medicine, Children's National Medical Center, Washington, DC, USA.
出版信息
Clin Neurophysiol. 2014 Jul;125(7):1353-9. doi: 10.1016/j.clinph.2013.11.018. Epub 2013 Dec 1.
OBJECTIVE
To identify quantitative MEG indices of spontaneous brain activity for fetal neurological maturation in normal pregnancies and examine the effect of fetal state on these indices.
METHODS
Spontaneous MEG brain activity was examined in 22 low-risk fetal recordings with gestational age (GA) ranging from 30 to 37 weeks. As major quantitative characteristics of spontaneous activity, burst duration (BD) and interburst interval (IBI) were studied in correlation with GA and fetal state.
RESULTS
IBI showed a decrease with gestational age (-0.21 s/week, P=0.0031). This trend was only maintained in the quiet-sleep state. With respect to BD, no significant trends were detected with GA and state.
CONCLUSION
IBI can be quantified as a fetal brain maturational parameter. The decrease in IBI over gestation was similar to the trend reported in the preterm neonatal EEG studies. Quiet sleep could be the optimal state to study such MEG maturational indices.
SIGNIFICANCE
With further investigation, indices extracted from spontaneous fetal brain activity may serve as an early warning for fetal neurological distress.
目的
确定正常妊娠中胎儿神经成熟的自发脑活动的定量 MEG 指标，并研究胎儿状态对这些指标的影响。
方法
对 22 例低危胎儿进行了自发 MEG 脑活动检查，胎龄（GA）范围为 30 周至 37 周。作为自发活动的主要定量特征，研究了爆发持续时间（BD）和爆发间隔（IBI）与 GA 和胎儿状态的相关性。
结果
IBI 随胎龄呈下降趋势（每周减少 0.21 秒，P=0.0031）。这种趋势仅在安静睡眠状态下维持。关于 BD，GA 和状态均未检测到明显趋势。
结论
IBI 可作为胎儿脑成熟度的参数进行定量。胎龄过程中 IBI 的减少与早产儿脑电图研究中报道的趋势相似。安静睡眠可能是研究这种 MEG 成熟度指标的最佳状态。
意义
进一步研究后，自发胎儿脑活动中提取的指标可能成为胎儿神经窘迫的早期预警。
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