Department of Obstetrics and Gynaecology, University of Tuebingen, Tuebingen, Germany.
fMEG-Center, University of Tuebingen, Tuebingen, Germany.
BJOG. 2015 Aug;122(9):1184-90. doi: 10.1111/1471-0528.13347. Epub 2015 Apr 2.
Fetal magnetoencephalography records fetal brain activity non-invasively. Delayed brain responses were reported for fetuses weighing below the tenth percentile. To investigate whether this delay indicates delayed brain maturation resulting from placental insufficiency, this study distinguished two groups of fetuses below the tenth percentile: growth-restricted fetuses with abnormal umbilical artery Doppler velocity (IUGR) and constitutionally small-for-gestational-age fetuses with normal umbilical artery Doppler findings (SGA) were compared with fetuses of adequate weight for gestational age (AGA), matched for age and behavioural state.
A case-control study of matched pairs.
Fetal magnetoencephalography-Center at the University Hospital of Tuebingen.
Fourteen IUGR fetuses and 23 SGA fetuses were matched for gestational age and fetal behavioural state with 37 healthy, normal-sized fetuses.
A 156-channel fetal magentoencephalography system was used to record fetal brain activity. Light flashes as visual stimulation were applied to the fetus. The Student's t-test for paired groups was performed.
Latency of fetal visual evoked magnetic responses (VER).
The IUGR fetuses showed delayed VERs compared with controls (IUGR, 233.1 ms; controls, 184.6 ms; P = 0.032). SGA fetuses had similar evoked response latencies compared with controls (SGA, 216.1 ms; controls, 219.9 ms; P = 0.828). Behavioural states were similarly distributed.
Visual evoked responses are delayed in IUGR fetuses, but not in SGA. Fetal behavioural state as an influencing factor of brain response latency was accounted for in the comparison. This reinforces that delayed brain maturation is the result of placental insufficiency.
胎儿脑磁图记录胎儿大脑活动是无创的。据报道，体重低于第十个百分位数的胎儿脑反应存在延迟。为了研究这种延迟是否表明由于胎盘功能不全导致大脑成熟延迟，本研究将低于第十个百分位数的胎儿分为两组：生长受限且脐动脉多普勒速度异常的胎儿（IUGR）和大小符合胎龄但脐动脉多普勒正常的胎儿（SGA），并与胎龄适当的胎儿（AGA）进行比较，AGA 按年龄和行为状态匹配。
配对病例对照研究。
图宾根大学医院胎儿脑磁图中心。
14 例 IUGR 胎儿和 23 例 SGA 胎儿，根据胎龄和胎儿行为状态与 37 例健康、正常大小的胎儿相匹配。
使用 156 通道胎儿磁脑图系统记录胎儿大脑活动。用闪光作为视觉刺激应用于胎儿。采用配对组学生 t 检验进行分析。
胎儿视觉诱发电磁反应（VER）潜伏期。
与对照组相比，IUGR 胎儿的 VER 潜伏期延长（IUGR，233.1 ms；对照组，184.6 ms；P = 0.032）。SGA 胎儿的诱发电应潜伏期与对照组相似（SGA，216.1 ms；对照组，219.9 ms；P = 0.828）。行为状态分布相似。
IUGR 胎儿的视觉诱发电应延迟，但 SGA 胎儿没有。在比较中考虑了大脑反应潜伏期的行为状态这一影响因素。这进一步证实了大脑成熟延迟是胎盘功能不全的结果。
