Vaccine Research Center, NIAID, National Institutes of Health, Bethesda, MD, USA.
Curr Top Microbiol Immunol. 2013;372:83-104. doi: 10.1007/978-3-642-38919-1_4.
The two major glycoproteins on the surface of the respiratory syncytial virus (RSV) virion, the attachment glycoprotein (G) and the fusion glycoprotein (F), control the initial phases of infection. G targets the ciliated cells of the airways, and F causes the virion membrane to fuse with the target cell membrane. The F protein is the major target for antiviral drug development, and both G and F glycoproteins are the antigens targeted by neutralizing antibodies induced by infection. In this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs antigen selection and vaccine development.
呼吸道合胞病毒(RSV)病毒粒子表面的两种主要糖蛋白,即附着糖蛋白(G)和融合糖蛋白(F),控制着感染的初始阶段。G 靶向气道的纤毛细胞,F 导致病毒包膜与靶细胞膜融合。F 蛋白是抗病毒药物开发的主要靶点,G 和 F 糖蛋白都是感染诱导的中和抗体靶向的抗原。在本章中,我们回顾了 RSV 表面糖蛋白的结构和功能,包括 F 糖蛋白在预融合和融合构象下的最新 X 射线晶体学数据,并讨论了这些信息如何为抗原选择和疫苗开发提供信息。