通过 Bischler-Napieralski 型环化反应从异丙基氨基甲酸酯中合成平滑的异吲哚啉酮。
Smooth isoindolinone formation from isopropyl carbamates via Bischler-Napieralski-type cyclization.
机构信息
Department of Applied Chemistry, Faculty of Science and Technology, Keio University , 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
出版信息
Org Lett. 2014 Jan 17;16(2):358-61. doi: 10.1021/ol403142d. Epub 2013 Dec 23.
PMID:24364475
Abstract
Isopropyl carbamates derived from benzylamines provide isoindolinones by treatment with phosphorus pentoxide at room temperature. Utility of this Bischler-Napieralski-type cyclization and a new mechanism involving a carbamoyl cation for rationalization of this smooth conversion are discussed.
摘要
由苄胺衍生的异丙基氨基甲酸酯在室温下用五氧化二磷处理提供异吲哚啉酮。讨论了这种 Bischler-Napieralski 型环化反应的实用性以及涉及碳酰胺阳离子的新机制，以合理化这种顺利转化。
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