Bao Yong-Sheng, Zhaorigetu Bao, Agula Bao, Baiyin Menghe, Jia Meilin
College of Chemistry and Environmental Science, Inner Mongolia Key Laboratory of Green Catalysis, Inner Mongolia Normal University , Hohhot 010022, China .
J Org Chem. 2014 Jan 17;79(2):803-8. doi: 10.1021/jo4023974. Epub 2013 Dec 31.
An aminolysis reaction between various aryl esters and inert tertiary amines by C-O and C-N bond activations has been developed for the selective synthesis of a broad scope of tertiary amides under neutral and mild conditions. The mechanism may undergo the two key steps of oxidative addition of acyl C-O bond in parent ester and C-N bond cleavage of tertiary amine via an iminium-type intermediate.
通过C-O和C-N键活化，已开发出各种芳基酯与惰性叔胺之间的氨解反应，用于在中性温和条件下选择性合成多种叔酰胺。该机理可能经历母体酯中酰基C-O键的氧化加成和通过亚胺型中间体的叔胺C-N键裂解这两个关键步骤。
