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由苯基酯和芳基胺进行无溶剂和无过渡金属的酰胺合成。

Solvent- and transition metal-free amide synthesis from phenyl esters and aryl amines.

作者信息

Rzhevskiy Sergey A, Ageshina Alexandra A, Chesnokov Gleb A, Gribanov Pavel S, Topchiy Maxim A, Nechaev Mikhail S, Asachenko Andrey F

机构信息

A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Leninsky Prospect 29 Moscow 119991 Russia

M.V. Lomonosov Moscow State University Leninskie Gory 1 (3) Moscow 119991 Russia

出版信息

RSC Adv. 2019 Jan 11;9(3):1536-1540. doi: 10.1039/c8ra10040c. eCollection 2019 Jan 9.

DOI:10.1039/c8ra10040c
PMID:35518015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9059645/
Abstract

A general, economical, and environmentally friendly method of amide synthesis from phenyl esters and aryl amines was developed. This new method has significant advantages compared to previously reported palladium-catalyzed approaches. The reaction is performed transition metal- and solvent-free, using a cheap and environmentally benign base, NaH. This approach enabled us to obtain target amides in high yields with high atom economy.

摘要

开发了一种由苯基酯和芳基胺合成酰胺的通用、经济且环保的方法。与先前报道的钯催化方法相比，这种新方法具有显著优势。该反应在无过渡金属和无溶剂的条件下进行，使用廉价且对环境友好的碱氢化钠（NaH）。这种方法使我们能够以高原子经济性高产率获得目标酰胺。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a55/9059645/887bd7d9dea7/c8ra10040c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a55/9059645/887bd7d9dea7/c8ra10040c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a55/9059645/887bd7d9dea7/c8ra10040c-s1.jpg

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