Schmidt-Hieber Christoph, Häusser Michael
Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, , Gower Street, London WC1E 6BT, UK.
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20120520. doi: 10.1098/rstb.2012.0520. Print 2014 Feb 5.
Neurons in the medial entorhinal cortex fire action potentials at regular spatial intervals, creating a striking grid-like pattern of spike rates spanning the whole environment of a navigating animal. This remarkable spatial code may represent a neural map for path integration. Recent advances using patch-clamp recordings from entorhinal cortex neurons in vitro and in vivo have revealed how the microcircuitry in the medial entorhinal cortex may contribute to grid cell firing patterns, and how grid cells may transform synaptic inputs into spike output during firing field crossings. These new findings provide key insights into the ingredients necessary to build a grid cell.
内侧内嗅皮层中的神经元以规则的空间间隔发放动作电位，在导航动物的整个环境中形成一种显著的、类似网格的放电率模式。这种非凡的空间编码可能代表了用于路径整合的神经地图。最近利用体外和体内内嗅皮层神经元的膜片钳记录取得的进展，揭示了内侧内嗅皮层中的微电路如何可能促成网格细胞的放电模式，以及网格细胞在穿越放电野期间如何将突触输入转化为动作电位输出。这些新发现为构建网格细胞所需的要素提供了关键见解。
