Fernández-Ruiz Antonio, Oliva Azahara, Nagy Gergő A, Maurer Andrew P, Berényi Antal, Buzsáki György
MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary; New York University Neuroscience Institute, New York University, New York, NY 10016, USA.
MTA-SZTE "Momentum" Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged, Szeged 6720, Hungary.
Neuron. 2017 Mar 8;93(5):1213-1226.e5. doi: 10.1016/j.neuron.2017.02.017.
Theta-gamma phase coupling and spike timing within theta oscillations are prominent features of the hippocampus and are often related to navigation and memory. However, the mechanisms that give rise to these relationships are not well understood. Using high spatial resolution electrophysiology, we investigated the influence of CA3 and entorhinal inputs on the timing of CA1 neurons. The theta-phase preference and excitatory strength of the afferent CA3 and entorhinal inputs effectively timed the principal neuron activity, as well as regulated distinct CA1 interneuron populations in multiple tasks and behavioral states. Feedback potentiation of distal dendritic inhibition by CA1 place cells attenuated the excitatory entorhinal input at place field entry, coupled with feedback depression of proximal dendritic and perisomatic inhibition, allowing the CA3 input to gain control toward the exit. Thus, upstream inputs interact with local mechanisms to determine theta-phase timing of hippocampal neurons to support memory and spatial navigation.
θ-γ相位耦合以及θ振荡内的尖峰时间是海马体的显著特征，并且常常与导航和记忆相关。然而，产生这些关系的机制尚未得到很好的理解。利用高空间分辨率电生理学，我们研究了CA3和内嗅皮层输入对CA1神经元时间的影响。传入的CA3和内嗅皮层输入的θ相位偏好和兴奋性强度有效地确定了主神经元活动的时间，并且在多种任务和行为状态下调节了不同的CA1中间神经元群体。CA1位置细胞对远端树突抑制的反馈增强在位置场进入时减弱了兴奋性内嗅皮层输入，同时近端树突和胞体周围抑制的反馈减弱，使得CA3输入在出口处获得控制权。因此，上游输入与局部机制相互作用，以确定海马体神经元的θ相位时间，从而支持记忆和空间导航。
