Page Hector J I, Walters Daniel M, Knight Rebecca, Piette Caitlin E, Jeffery Kathryn J, Stringer Simon M
Oxford Centre for Theoretical Neuroscience and Artificial Intelligence, Departmental of Experimental Psychology, University of Oxford, , South Parks Road, Oxford OX1 3UD, UK.
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 23;369(1635):20130283. doi: 10.1098/rstb.2013.0283. Print 2014 Feb 5.
Head direction (HD) cell responses are thought to be derived from a combination of internal (or idiothetic) and external (or allothetic) sources of information. Recent work from the Jeffery laboratory shows that the relative influence of visual versus vestibular inputs upon the HD cell response depends on the disparity between these sources. In this paper, we present simulation results from a model designed to explain these observations. The model accurately replicates the Knight et al. data. We suggest that cue conflict resolution is critically dependent on plastic remapping of visual information onto the HD cell layer. This remap results in a shift in preferred directions of a subset of HD cells, which is then inherited by the rest of the cells during path integration. Thus, we demonstrate how, over a period of several minutes, a visual landmark may gain cue control. Furthermore, simulation results show that weaker visual landmarks fail to gain cue control as readily. We therefore suggest a second longer term plasticity in visual projections onto HD cell areas, through which landmarks with an inconsistent relationship to idiothetic information are made less salient, significantly hindering their ability to gain cue control. Our results provide a mechanism for reliability-weighted cue averaging that may pertain to other neural systems in addition to the HD system.
头部方向（HD）细胞的反应被认为源自内部（或自身感受性）和外部（或异感受性）信息源的组合。杰弗里实验室最近的研究表明，视觉输入与前庭输入对HD细胞反应的相对影响取决于这些信息源之间的差异。在本文中，我们展示了一个旨在解释这些观察结果的模型的模拟结果。该模型准确地复制了奈特等人的数据。我们认为，线索冲突的解决关键取决于视觉信息在前庭细胞层上的可塑性重映射。这种重映射导致一部分HD细胞的偏好方向发生偏移，然后在路径整合过程中被其余细胞继承。因此，我们展示了在几分钟的时间内，视觉地标如何获得线索控制权。此外，模拟结果表明，较弱的视觉地标不太容易获得线索控制权。因此，我们提出视觉投射到HD细胞区域存在第二种长期可塑性，通过这种可塑性，与自身感受性信息关系不一致的地标变得不那么突出，从而显著阻碍它们获得线索控制权的能力。我们的结果提供了一种可靠性加权线索平均的机制，除了HD系统外，可能还适用于其他神经系统。
