Zerbo Ousseny, Qian Yinge, Yoshida Cathleen, Grether Judith K, Van de Water Judy, Croen Lisa A
Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, 94612, USA.
, Richmond, CA, USA.
J Autism Dev Disord. 2015 Dec;45(12):4015-25. doi: 10.1007/s10803-013-2016-3.
We conducted a nested case-control study including 407 cases and 2,075 frequency matched controls to investigate the association between maternal infections during pregnancy and risk of autism spectrum disorders (ASD). Cases, controls, and maternal infections were ascertained from Kaiser Permanente Northern California clinical databases. No overall association between diagnoses of any maternal infection during pregnancy and ASD was observed [adjusted odds ratio (ORadj) = 1.15, 95 % confidence interval (CI) 0.92-1.43]. However, women with infections diagnosed during a hospital admission (ORadj = 1.48, 95 % CI 1.07-2.04), particularly bacterial infections (ORadj = 1.58, 95 % CI 1.06-2.37), were at increased risk of delivering a child with ASD. Multiple infections during pregnancy were associated with ASD (ORadj = 1.36, 95 % CI 1.05-1.78).
我们开展了一项巢式病例对照研究，纳入407例病例和2075例频率匹配的对照，以调查孕期母亲感染与自闭症谱系障碍（ASD）风险之间的关联。病例、对照和母亲感染情况均来自北加利福尼亚凯撒医疗集团的临床数据库。未观察到孕期任何母亲感染诊断与ASD之间存在总体关联[校正优势比（ORadj）=1.15，95%置信区间（CI）0.92 - 1.43]。然而，在住院期间被诊断感染的女性（ORadj = 1.48，95% CI 1.07 - 2.04），尤其是细菌感染（ORadj = 1.58，95% CI 1.06 - 2.37），生育患ASD孩子的风险增加。孕期多次感染与ASD相关（ORadj = 1.36，95% CI 1.05 - 1.78）。
