Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Department of Biochemistry and Molecular Genetics, American University of Beirut, Riad El Solh, P. O. Box 11-0236, Beirut, 1107 2020, Lebanon.
J Autism Dev Disord. 2018 Jun;48(6):2010-2021. doi: 10.1007/s10803-017-3449-x.
This case-control study explores the association between pregnancy/birth complications and other factors with Autism Spectrum Disorder (ASD) in Lebanese subjects aged 2-18 years. Researchers interviewed 136 ASD cases from the American University of Beirut Medical Center Special Kids Clinic, and 178 controls selected by systematic digit dialing in the Greater-Beirut area. Male gender (Adjusted Odds Ratio [95% CI]: 3.9 [2.2-7.0]); postpartum feeding difficulties (2.5 [1.2-5.4]); maternal infections/complications during pregnancy (2.9 [1.5-5.5], 2.1 [1.1-3.9]); consanguinity (2.5 [1.0-6.0]); family history of psychiatric disorders (2.2 [1.1-4.4]) were risk factors for ASD. Being born first/second (0.52 [0.28-0.95]) and maternal psychological support during pregnancy (0.49 [0.27-0.89]) were negatively associated with ASD. Identifying ASD correlates is crucial for instigating timely screening and subsequent early intervention.
本病例对照研究旨在探讨黎巴嫩 2-18 岁儿童中妊娠/分娩并发症及其他因素与自闭症谱系障碍（ASD）之间的关联。研究人员对贝鲁特美国大学医学中心特殊儿童诊所的 136 例 ASD 病例和大贝鲁特地区通过系统数字拨号选择的 178 例对照进行了访谈。男性（调整后的优势比[95%置信区间]：3.9 [2.2-7.0]）；产后喂养困难（2.5 [1.2-5.4]）；母亲在怀孕期间感染/并发症（2.9 [1.5-5.5]，2.1 [1.1-3.9]）；近亲结婚（2.5 [1.0-6.0]）；家族精神病史（2.2 [1.1-4.4]）均为 ASD 的危险因素。先/二胎出生（0.52 [0.28-0.95]）和母亲在怀孕期间的心理支持（0.49 [0.27-0.89]）与 ASD 呈负相关。确定 ASD 的相关因素对于及时进行筛查和随后的早期干预至关重要。
