Department of Neurology, Albany Medical Center , Albany, NY , USA.
Department of Neurology, Maguire Center, Stritch School of Medicine, Loyola University Chicago , Maywood, IL , USA.
Front Neurol. 2013 Dec 6;4:197. doi: 10.3389/fneur.2013.00197. eCollection 2013.
Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system lymphoma or systemic lymphoma. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve. Infiltration of brain parenchyma, meninges or Virchow-Robin spaces is characteristic of systemic disease at autopsy. We describe a patient presenting with biopsy negative NL affecting exclusively the peripheral nervous system at autopsy.
神经淋巴病（NL）是指与中枢神经系统或全身淋巴瘤相关的周围神经的淋巴瘤浸润，或者另外，在原发性中枢神经系统淋巴瘤或全身淋巴瘤的情况下，神经诊断证据显示神经强化和/或超出硬脑膜鞘的扩大。NL 是一种罕见的全身癌症并发症，具有异质的临床表现和难以捉摸的诊断。诊断通常需要在外周神经中显示浸润的恶性淋巴细胞。在尸检中，脑实质、脑膜或 Virchow-Robin 空间的浸润是全身疾病的特征。我们描述了一个在尸检中仅表现为活检阴性 NL 影响外周神经系统的患者。
