Laycock S M, Smith H, Spicer B A
Int Arch Allergy Appl Immunol. 1987;82(3-4):347-8. doi: 10.1159/000234223.
The intravenous injection of Sephadex particles (G200) into rats produced a specific increase in numbers of blood eosinophils, peaking 7 days later. A second injection, given on day 14 when the numbers of blood eosinophils had fallen to control levels, produced a dose-dependent increase in numbers, greater than the first, and peaking 5 days later. At this time, there was a dose-dependent increase in numbers of eosinophils, but not of other leucocytes, in broncho-alveolar lavage fluids and lung tissue, together with an increase in sensitivity of the rats to the respiratory effects produced by the intravenous injection of 5-hydroxytryptamine.
给大鼠静脉注射葡聚糖凝胶颗粒（G200）后，血液嗜酸性粒细胞数量出现特异性增加，7天后达到峰值。在第14天血液嗜酸性粒细胞数量已降至对照水平时进行第二次注射，其数量呈剂量依赖性增加，增幅大于第一次，5天后达到峰值。此时，支气管肺泡灌洗液和肺组织中的嗜酸性粒细胞数量呈剂量依赖性增加，而其他白细胞数量未增加，同时大鼠对静脉注射5-羟色胺产生的呼吸效应的敏感性增加。
