Spicer B A, Baker R, Laycock S M, Smith H
Beecham Pharmaceuticals Research Division, Epsom, Surrey, UK.
Agents Actions. 1989 Jan;26(1-2):63-5.
The injection of Sephadex particles intravenously into rats produced a specific blood eosinophilia and an hyper-responsiveness of the airways to 5-hydroxytryptamine (5-HT). The rats given Sephadex had an hyper-sensitivity to the respiratory effects of 5-HT in vivo with a shift to the left of the intravenous dose response curve. In vitro lung strips from rats given Sephadex were hyper-reactive to 5-HT in that the strips from these rats and control rats responded over the same dose range of 5-HT but the slope of the dose response curve and the maximum response were greater in the strips from the Sephadex treated rats. The levels of hyper-sensitivity in vivo and of hyper-reactivity in vitro both correlated with the numbers of blood eosinophils.
给大鼠静脉注射葡聚糖颗粒可导致特异性血液嗜酸性粒细胞增多以及气道对5-羟色胺（5-HT）的反应性增强。给予葡聚糖的大鼠在体内对5-HT的呼吸效应具有超敏反应，静脉注射剂量反应曲线向左偏移。来自给予葡聚糖的大鼠的体外肺条对5-HT反应性增强，即这些大鼠和对照大鼠的肺条在相同的5-HT剂量范围内有反应，但给予葡聚糖处理的大鼠的肺条剂量反应曲线的斜率和最大反应更大。体内超敏反应水平和体外高反应性均与血液嗜酸性粒细胞数量相关。
