Foreman J C
Int Arch Allergy Appl Immunol. 1987;82(3-4):366-71. doi: 10.1159/000234229.
Mast cells are found in close association with blood vessels, and histamine is known to be a potent vasodilator in humans. It is now clear that mast cells form neuroeffector junctions and that one of the types of nerve involved is the peptide-containing primary afferent neurone (C fibre). Nerve stimulation produces vasodilation which is blocked by antihistamines or by depletion of mast cell histamine with compound 48/80. Nerve stimulation also releases histamine and degranulates mast cells. Substance P and other neuropeptides release histamine from isolated rat and human skin mast cells. The actions of substance P and calcitonin gene-related peptide in human skin are compatible with a role for these two peptides in neurogenic inflammation. The inflammatory effects of substance P in human skin are inhibited by antihistamines. The possible role of the mast cell in neurogenic inflammation is discussed.
肥大细胞与血管紧密相连，组胺在人体中是一种有效的血管扩张剂。现在已经清楚，肥大细胞形成神经效应器连接，其中一种参与的神经类型是含肽的初级传入神经元（C纤维）。神经刺激会产生血管舒张，这可被抗组胺药或用化合物48/80耗尽肥大细胞组胺所阻断。神经刺激还会释放组胺并使肥大细胞脱颗粒。P物质和其他神经肽可从分离的大鼠和人皮肤肥大细胞中释放组胺。P物质和降钙素基因相关肽在人皮肤中的作用与这两种肽在神经源性炎症中的作用相符。抗组胺药可抑制P物质在人皮肤中的炎症作用。本文讨论了肥大细胞在神经源性炎症中的可能作用。
