Dumitru Luminita, Iliescu Alina, Dinu Horatiu, Badea Ruxandra, Savulescu Simona, Huidu Simona, Berteanu Mihai
Elias Emergency University Hospital, Department of Physical and Rehabilitation Medicine, Bucharest, Romania.
Elias Emergency University Hospital, Department of Cardiology, Bucharest, Romania.
Maedica (Bucur). 2013 Jun;8(2):206-13.
Chronic Obstructive Pulmonary Disease (COPD) and Chronic Heart Failure (CHF), two major causes of worldwide morbidity and mortality have important systemic components, affecting additional tissues, other than the lung or the heart, such as the skeletal muscle. Muscle function (or dysfunction) may not only influence the symptoms that limit exercise, but may contribute directly to the poor exercise performance, health status and increased healthcare utilization.The present review tries to summarize the muscular abnormalities in COPD and CHF and the mechanisms underlying these alterations, which are strikingly similar, despite the obvious differences concerning the primary impairment in these two chronic diseases.The muscles therefore represent a potential site to improve patients' functioning level and quality of life of COPD and CHF. Only one practical therapeutic intervention currently exists that can reverse some of the muscle abnormalities observed in COPD and CHF, namely exercise training, which becomes nowadays the "cornerstone" of the whole rehabilitation.
慢性阻塞性肺疾病（COPD）和慢性心力衰竭（CHF）是全球发病和死亡的两大主要原因，它们具有重要的全身影响，除了肺或心脏外，还会影响其他组织，如骨骼肌。肌肉功能（或功能障碍）不仅可能影响限制运动的症状，还可能直接导致运动能力差、健康状况不佳以及医疗保健利用率增加。本综述试图总结COPD和CHF中的肌肉异常情况以及这些改变背后的机制，尽管这两种慢性疾病的原发性损伤存在明显差异，但这些机制却惊人地相似。因此，肌肉是改善COPD和CHF患者功能水平和生活质量的潜在靶点。目前只有一种切实可行的治疗干预措施可以逆转在COPD和CHF中观察到的一些肌肉异常，即运动训练，如今运动训练已成为整个康复过程的“基石”。
