Mehani Sherin Hassan M
Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Beni-Suef University: Benisuef Elgadata, Street no.18, Benisuef governorate, Egypt.
J Phys Ther Sci. 2017 Sep;29(9):1527-1533. doi: 10.1589/jpts.29.1527. Epub 2017 Sep 15.
[Purpose] Counteracting the systemic cytokine release and its inflammatory effects by improving respiratory muscle strength and controlling lung inflammation may be important for improving immune system in patients with chronic obstructive pulmonary disease, So the aim of the present study was to evaluate the effect of low level laser therapy and inspiratory muscle training on interleukin-6 (IL-6) as a marker of inflammation and CD4+/CD8+ ratio as a marker for T Lymphocytes in these patients. [Subjects and Methods] Forty male patients with stable COPD participated in the study, their ages ranged between 55-65 years. They were randomly divided into group (A) who received inspiratory muscle training and group (B) who received low level laser (LLL) acupuncture stimulation for about 8 week. [Results] There was a reduction in the concentration of plasma IL-6 associated with an increase in CD4+/CD8+ ratio in both groups, but laser was superior to inspiratory muscle training. IL-6 and CD4+/CD8+ were negatively correlated. [Conclusion] Both inspiratory muscle training and low level laser therapy are effective physical therapy modalities in promoting immune disturbances. The results also supported the superior role of LLLT over IMT in managing immune disturbances.
[目的] 通过增强呼吸肌力量和控制肺部炎症来对抗全身细胞因子释放及其炎症效应，对于改善慢性阻塞性肺疾病患者的免疫系统可能至关重要。因此，本研究的目的是评估低强度激光疗法和吸气肌训练对作为炎症标志物的白细胞介素-6（IL-6）以及作为这些患者T淋巴细胞标志物的CD4+/CD8+比值的影响。[对象与方法] 40例稳定期慢性阻塞性肺疾病男性患者参与研究，年龄在55 - 65岁之间。他们被随机分为接受吸气肌训练的A组和接受低强度激光（LLL）针刺刺激约8周的B组。[结果] 两组患者血浆IL-6浓度均降低，同时CD4+/CD8+比值升高，但激光疗法优于吸气肌训练。IL-6与CD4+/CD8+呈负相关。[结论] 吸气肌训练和低强度激光疗法都是促进免疫紊乱的有效物理治疗方式。结果还支持了低强度激光疗法在管理免疫紊乱方面优于吸气肌训练的作用。
