Rauch H C, Montgomery I N, Hinman C L, Harb W
J Neuroimmunol. 1987 May;15(1):73-83. doi: 10.1016/0165-5728(87)90007-5.
The concentration of myelin basic protein (MBP) in cerebrospinal fluid (CSF) correlates with the development of experimental allergic encephalomyelitis following intradermal injection with encephalitogen in adjuvant; MBP is absent in controls inoculated with adjuvants only. The presence of MBP is a sensitive indicator of disease inasmuch as CNS-inoculated mice with neurologic signs had an average of 0.29 ng/microliter of MBP in their CSF and controls, including normal or adjuvants only, had an average of 0.03 ng/microliter. The amount present per microliter of CSF, as well as the absolute amount, obtained from an individual mouse do not always reflect the severity of disease as indicated by clinical signs and the pathology observed in a sampling of the neuraxis. The presence of MBP does correlate with demyelination, although the extent of pathology observed by light microscopy in the mouse model is minimal, associated only with the inflammatory response, and does not extend beyond the zone of the perivascular cuff.
脑脊液（CSF）中髓鞘碱性蛋白（MBP）的浓度与在佐剂中皮内注射脑脊髓炎原后实验性变应性脑脊髓炎的发展相关；仅接种佐剂的对照组中不存在MBP。MBP的存在是疾病的一个敏感指标，因为出现神经体征的经中枢神经系统接种的小鼠脑脊液中MBP平均为0.29纳克/微升，而对照组，包括正常小鼠或仅接种佐剂的小鼠，平均为0.03纳克/微升。从每只小鼠获得的每微升脑脊液中的含量以及绝对含量并不总是反映临床体征和在神经轴取样中观察到的病理学所表明的疾病严重程度。MBP的存在确实与脱髓鞘相关，尽管在小鼠模型中通过光学显微镜观察到的病理学程度最小，仅与炎症反应相关，且不超出血管周围套区。
