从圆犁头鳐（Himantura pastinacoides）中鉴定出一种组蛋白衍生的假定抗菌肽Himanturin及其系统发育意义。
Identification of a histone derived, putative antimicrobial peptide Himanturin from round whip ray Himantura pastinacoides and its phylogenetic significance.
作者信息
Sathyan Naveen, Philip Rosamma, Chaithanya E R, Anil Kumar P R, Antony Swapna P
机构信息
Department of Marine Biology, Microbiology and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Fine Arts Avenue, Kochi 682016, Kerala, India.
出版信息
Results Immunol. 2012 Jun 26;2:120-4. doi: 10.1016/j.rinim.2012.06.001. eCollection 2012.
Abstract
Histone H2A participates in host defense responses by producing antimicrobial peptides (AMPs). The present study deals with identification of a putative antimicrobial sequence, Himanturin from the histone H2A of Round Whip Ray, Himantura pastinacoides. A 204 bp fragment encoding 68 amino acid residues was amplified from cDNA of Round Whip Ray, H. pastinacoides. Himanturin exhibited high similarity to previously reported histone H2A derived AMPs indicating the presence of an antimicrobial sequence motif. Physicochemical properties of Himanturin suggest it to be a potential antimicrobial candidate.
摘要
组蛋白H2A通过产生抗菌肽（AMPs）参与宿主防御反应。本研究旨在鉴定一种推定的抗菌序列，即来自圆犁头鳐（Himantura pastinacoides）组蛋白H2A的犁头鳐抗菌肽。从圆犁头鳐（H. pastinacoides）的cDNA中扩增出一个编码68个氨基酸残基的204 bp片段。犁头鳐抗菌肽与先前报道的源自组蛋白H2A的抗菌肽具有高度相似性，表明存在抗菌序列基序。犁头鳐抗菌肽的物理化学性质表明它是一种潜在的抗菌候选物。
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