食管念珠菌病与鳞状细胞癌的关联。
Association of esophageal candidiasis and squamous cell carcinoma.
作者信息
Delsing C E, Bleeker-Rovers C P, van de Veerdonk F L, Tol J, van der Meer J W M, Kullberg B J, Netea M G
机构信息
Department of Medicine and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Department of medical oncology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
出版信息
Med Mycol Case Rep. 2012 Mar 1;1(1):5-8. doi: 10.1016/j.mmcr.2012.02.003. eCollection 2012.
Abstract
Chronic esophageal candidiasis is an infection that is mostly seen in immunocompromised conditions, among which is chronic mucocutaneous candidiasis (CMC). Recently an association between CMC and esophageal carcinoma has been reported. Here we present two patients with chronic esophageal candidiasis who developed esophageal squamous cell carcinoma and we discuss the etiologic role of Candida-induced nitrosamine production, the loss of STAT1 function and impaired tumor surveillance and T-lymphocyte function in the development of esophageal carcinoma.
摘要
慢性食管念珠菌病是一种主要见于免疫功能低下状态的感染，其中包括慢性黏膜皮肤念珠菌病（CMC）。最近有报道称CMC与食管癌之间存在关联。在此，我们报告两名患有慢性食管念珠菌病并发展为食管鳞状细胞癌的患者，并讨论念珠菌诱导亚硝胺产生、信号转导和转录激活因子1（STAT1）功能丧失以及肿瘤监测和T淋巴细胞功能受损在食管癌发生中的病因学作用。
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