急性髓系白血病患者的头状地霉败血症。三例报告。
Geotrichum capitatum septicemia in patients with acute myeloid leukemia. Report of three cases.
作者信息
Saghrouni Fatma, Abdeljelil Jihene Ben, Youssef Yosra Ben, Abdeljelil Nour Ben, Gheith Soukeina, Fathallah Akila, Said Moncef Ben
机构信息
Laboratoire de parasitologie-mycologie, hôpital Farhat Hached, CHU Farhat Hached, Sousse, Tunisia.
Service d'hématologie clinique, CHU Farhat Hached, Sousse, Tunisia.
出版信息
Med Mycol Case Rep. 2012 Sep 26;1(1):88-90. doi: 10.1016/j.mmcr.2012.09.003. eCollection 2012.
Abstract
Geotrichum capitatum infection is uncommon, and has been exclusively reported in immunocompromised patients. The prognosis is poor with a mortality rate ranging from 50 to 90%. We report 3 cases of Geotrichum capitatum fungemia in neutropenic patients receiving chemotherapy for acute myeloblastic leukemia. The infection was successfully cured with voriconazole in 1 case and was fatal in the 2 remaining cases despite treatment with amphotericin B.
摘要
头状地霉感染并不常见，仅在免疫功能低下的患者中报道过。预后较差，死亡率在50%至90%之间。我们报告了3例急性髓细胞白血病接受化疗的中性粒细胞减少患者发生头状地霉真菌血症的病例。1例患者使用伏立康唑成功治愈感染，其余2例尽管使用两性霉素B治疗仍死亡。
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