中性粒细胞减少患者的头状地霉败血症：病例报告及文献复习

Geotrichum capitatum septicaemia in neutropenic patients: case report and review of the literature.

作者信息

Schiemann R, Glasmacher A, Bailly E, Horré R, Molitor E, Leutner C, Smith M T, Kleinschmidt R, Marklein G, Sauerbruch T

机构信息

Medizinische Klinik, Rheinische Friedrich-Wilhems-Universität Bonn, Germany.

出版信息

Mycoses. 1998 Mar-Apr;41(3-4):113-6. doi: 10.1111/j.1439-0507.1998.tb00311.x.

DOI:10.1111/j.1439-0507.1998.tb00311.x

PMID:9670762

Abstract

We report a case of systemic infection with Geotrichum capitatum in a patient with acute myeloid leukaemia. Three days before death, the patient developed acute renal failure, probably caused by occlusion of glomerula with hyphae of G. capitatum. Up until now, prophylaxis and treatment of infections caused by Geotrichum capitatum have not been established. However, the prophylactic administration of high-dose itraconazole and the therapeutic use of liposomal amphotericin B are subjects of discussion.

摘要

我们报告了1例急性髓系白血病患者发生头状地霉全身感染的病例。患者在死亡前3天出现急性肾衰竭，可能是由头状地霉的菌丝阻塞肾小球所致。迄今为止，头状地霉所致感染的预防和治疗方法尚未确立。然而，高剂量伊曲康唑的预防性给药以及脂质体两性霉素B的治疗应用是讨论的话题。